Process Engineering |
The main focuses of the Process Engineering unit are development and testing of membrane and adsorption processes, the measurement of sieving coefficients for important plasma components (albumin, total protein, HDL, LDL, immunoglobulins, fibrinogin, uremic markers) as well as the pressure and flow measurements of the extracorporeal blood purification membranes in order to make a rheological characterization. |
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| Furthermore, in this unit adsorber material is tested in regards to its adsorption capacity and adsorption kinetics in batch-tests and especially in the whole system as it will be used clinically. The following substances, among others, will be used for the effectiveness of the system in case of liver failure: bilirubin which strongly binds to albumin, bile acids (glycocholic acid, taurocholic acid), aromatic amino acids (tryptophan, phenylalanine, tyrosine for the establishment of the Fischer's Ratio) and phenole. |
In the Process Engineering unit, the blood purification system are tested in close cooperation with our partners and with regard to its efficacy (filtration rates, adsorption kinetics, flow rate and pressure) it will be specified and optimized. |
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The manufactured micro- and nanoparticles which will be used in the adsorption system are specified according to size and size and volume distribution in the process engineering laboratory. (see figure on left) |
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