Science

Stroke is the second most frequent cause of death and cognitive deficits including dementia occur frequently following stroke. The frequency of cognitive disturbances has been reported up to 30% and thus occurs three times more frequent than recurrent stroke. Aim of this randomized controlled study is to test if intensive polyintervention therapy, including life style modifications targeting at reduction of modifiable risk factors of stroke, can reduce the risk of post-stroke cognitive decline.

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In May 2011, the project e-PREDICE (Early prevention of diabetes complications in people with hyperglycaemia in Europe) of the Department of Clinical Medicine and Preventive Medicine has been evaluated favourably for a Grant by the European Commission. E-PREDICE aims at testing the long term efficacy of different therapeutic schemes for the early prevention of diabetic complications in people with hyperglycaemia currently under lifestyle intervention.

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The accurate and rapid recognition of stroke reduces prehospital time delays and makes acute therapy possible. Data of stroke cases identified incorrectly as stroke will be analysed to identify variables distinguishing them from “real” strokes.

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The department for Clinical Neurosciences and Preventive Medicine is engaged in a variety of clinical trials including pure academic trials and others sponsored by pharmaceutical industry. The special situation of having an office at the Neurological Department of the Donauklinikum Tulln opens the opportunity to involve medical specialists and physicians during their training in those trials. This allows both sides to profit from the synergetic potential between the Danube University and the Donauklinikum.

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Two to 30% of patients develop a pneumonia after stroke. Patients with post-stroke pneumonia have threefold increased risk of 30-day mortality and higher risk of bad outcome after one year. Independent predictor of post-stroke pneumonia will be identified.

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Demographic changes in the population, better medical care and better primary prevention are reflected in changes in the risk profile of stroke patients. Due to an increased transfer of stroke patients to stroke units, better diagnostic instruments and better stroke knowledge in the population, the number and type of strokes admitted to stroke units have changed. These changes in the stroke patient population have consequences for future prognoses regarding outcome. The knowledge of variations in characteristics of the target population facilitates an optimal adaptation of treatment strategies.

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