The Role of microvesicles from blood derived products in osteoarthritis

Center for Regenerative Medicine

Description

The chronic degenerative disease osteoarthritis affects around 60% of people worldwide and is characterized by a progressive degradation of the cartilage. Patients suffer from pain, invalidity and dramatic loss of life quality. Besides medicamentous treatments, transplantation of autologous chondrocytes, the only cells within the cartilage, or total knee replacement by an implant are the only therapies to improve the clinical picture of osteoarthritis. A new regenerative approach is the use of patient´s blood derivatives. Platelet-rich plasma (PRP) and hypACTTM serum are the two most prominent among these. These products are an enrichment of various factors (especially growth factors) which accelerate the healing process of cartilage defects. OrthoSera GmbH has developed the CE marked device hypACTTM inject. With this syringe blood from the patient can be retrieved, centrifuged and processed within the same medical procedure. The obtained hypACTTM serum within hypACTTM inject can then directly be injected into the defective side. Together with exosomes and apoptotic bodies, microvesicles form the group of the so called extracellular vesicles which represent a novel mechanism by which pathogenic signals are communicated among different cell types. Extracellular vesicles transport bioactive molecules from one cell to an other leading to a biological response within the target cell. The aim of this project is to isolate and characterize microvesicles from the blood derivatives PRP and hypACTTM serum in order to determine their regenerative potential to fight osteoarthritis. 

Cooperation partner:

CPRP

Details

Duration 01/01/2018 - 29/02/2020
Funding Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program Technologieförderung NÖ
Department

Department for Health Sciences, Medicine and Research

Center for Regenerative Medicine

Principle investigator for the project (Danube University Krems) Ass. Prof. Mag. Andrea De Luna, Ph.D.
Project members Univ.-Prof. Dr. Stefan Nehrer Alexander Otahal, MSc

Team

Publications

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy. Frontiers in Bioenfineering and Biotechnology, Volume 8: 10.3389/fbioe.2020.584050

Lectures

miRNAs enriched in extracellular vesicles in plasma and serum based autologous blood derived products for osteoarthritis therapy

YIRM, Krems, Österreich, 13/12/2019

miRNAs enriched in extracellular vesicles in plasma and serum based autologous blood derived products for osteoarthritis therapy

ASEV-GSEV joint meeting, Freising, Deutschland, 29/11/2019

Effects of extracellular vesicles from blood derivatives on osteoarthritic chondrocytes

ASEV/GSEV Joint Meeting, Freising, Deutschland, 28/11/2019

Anti-coagulation influences properties of extracellular vesicles isolated from autologous blood derived products used for cartilage repair

World Congress of the International cartilage repair and joint preservation society, Vancouver, Kanada, 08/10/2019

Coagulation influences properties of extracellular vesicles isolated from autologous blood derived products

TERMIS EU Chapter, Rhodos, Griechenland, 28/05/2019

Efficient clearance of lipoproteins from anti-coagulated and native blood derived products to yield pure extracellular vesicle preparations

TERMIS-EU, Rhodos, Griechenland, 28/05/2019

Efficient clearance of lipoproteins from anti-coagulated and native blood-derived products to yield pure extracellular vesicle preparations

ISEV, Kyoto, Japan, 26/04/2019

Blood derived products contain extracellular vesicles with distinct biological properties for regenerative approaches

Word Congress of the International Society of Extracellular Vesicles (ISEV), Kyoto, Japan, 25/04/2019

Characterisation of extracellular vesicles in different blood derived products for osteoarthritis therapy

ESAO Winter School, Baden, Österreich, 24/01/2019

Different production technology of blood derived products influences differentiation pathway of various cell populations

World Congress of the International Society of Tissue Engineering and Regenerative Medicine (TERMIS), Kyoto, Japan, 07/09/2018

Different production technology of blood derived products influences differentiation pathway of various cell populations

Gordon Research Conference on Extracellular Vesicles, Newry, USA, 21/08/2018

Different production technology of blood derived products influences differentiation pathway of various cell populations

14. World congress of the International cartilage repair society (ICRS) , Macau, China, 12/04/2018

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