Entwicklung eines Add-On MDS-Systems für extrakorporale Therapieverfahren

The treatment of acute liver failure and hepatic decompensation requires a broad basis of therapeutic methods. The functions of the liver in synthesizing and metabolic regulation can be well treated by substitutes based on classical methods. The detoxification function of the liver can hardly be achieved using conventional methods. The Microspheres based Detoxification Module (MDS) is designed for supporting the detoxification function of the liver by the specific elimination of toxins from the blood stream. The patient’s blood is, similar to a conventional dialysis treatment, circulated through an extracorporeal circuit and separated in a plasma filter into a cell and into a filtrate fraction. The filtrate fraction is directed into the MDS circuit and suspended with microparticles carrying a high specific surface for toxin binding and therefore toxin removal from the patient’s blood. To ensure a convenient daily use of the MDS module in a hospital ICU, it is designed as add-on system for conventional dialysis machines.