Monolithic Adsorbent Columns for Extracorporeal Blood Purification

Description

This interdisciplinary project deals with the development of monolithic adsorption columns for extracorporeal blood purification (haemapheresis), for cell separation (cytapheresis), and for other bioseparations. The specific aims of this project are (1) the synthesis of monolithic cryogels, (2) the synthesis of adsorbent particles with and without functionalisation with bioligands as well as the synthesis of activated carbons, (3) the production of composite adsorption columns containing the adsorbent particles embedded in a cryogel matrix, (4) the characterization of the biocompatibility of these materials, and (5) the evaluation of the adsorption characteristics (capacity, selectivity) for protiens and cells. The following partners are involved in the project: University of Brighton (coordinator), Mast Carbon Technology Ltd., Brighton and Sussex University Hospitals NHS Trust (all UK), Protista Biotechnology and Universität Lund (both Sweden), Polymerics GmbH (Germany), Danube University Krems (Austria). The focus of the work in krems is on the characterization of the newly developed materials with respect to adsorption properties and biocompatibility as well as on the synthesis of a new ligand for endotoxin.

Details

Duration 01/03/2008 - 28/02/2012
Funding EU
Program 7. Rahmenprogramm
Department

Department for Biomedical Research

Center for Biomedical Technology

Principle investigator for the project (Danube University Krems) Univ.-Prof. Dr. Viktoria Weber

Publications

Eichhorn, T.; Ivanov, A.E.; Dainiak, M. B.; Leistner, A.; Linsberger, I.; Jungvid, H.; Mikhalovsky, S. V.; Weber, V. (2013). Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood. Journal of Chemistry, 2013: 348412

Tripisciano, C.; Leistner, A.; Linsberger, I.; Leistner, A.; Falkenhagen, D.; Weber, V. (2012). Effect of anticoagulation with citrate versus heparin on the adsorption of coagulation factors to blood purification resins with different charge. Biomacromolecules, 13(2): 484-488

Tripisciano, C.; Kozynchenko, O.P.; Linsberger, I.; Phillips, G.J.; Howell, C.A.; Sandeman, S.R.; Tennison, S.R.; Mikhalovsky, S.V.; Weber, V.; Falkenhagen D. (2011). Activation-dependent adsorption of cytokines and toxins related to liver failure to carbon beads. Biomacromolecules, 12(10): 3733-3740

Lectures

Adsorption properties of carbon beads with highly developed nanoporosity

BioNanoMed 2013, 13.-15.03.2013, Krems, Austria, 13/03/2013

Effect of anticoagulation on the adsorption of critical coagulation factors by polymers with different charge and porosity

European Polymer Conference EUPOC 2012 - Porous polymer-based systems: from design to application, 03.-06.06.2012, Cargnano, Italy, 04/06/2012

Characterization of different activated carbon beads for blood purification: adsorption properties and biocompatibility analysis

4th Joint ESAO-IFAO Congress 2011, 09.-12.10.2011, Porto, Portugal, 11/10/2011

Adsorption Properties of Carbon Beads with Increasing Activation Degrees for Application in Blood Purification

ESAO-ASAIO Winter School 2011, 26.-29.01.2011, Semmering, Austria, 26/01/2011

Team

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