Development of adsorption therapies for sepsis using interactive cell culture models

Description

A cell culture model that has been established in an earlier project at the Center for Biomedical Technology will be applied to develop and optimise adsorbent-based blood purification for the supportive therapy of sepsis. The project focuses on (1) assessment of the effect of selective or specific mediator modulation (e.g. adsorption of endotoxin, cytokines, complement factors) on endothelial cell activation; (2) development of a model for the anti-inflammatory phase of sepsis, since a therapy acting at a later stage of sepsis would broaden the window for the clinical use of adsorption therapy.

Details

Duration 01/01/2010 - 31/12/2013
Funding FFG
Program FFG (Bridge)
Department

Department for Biomedical Research

Center for Biomedical Technology

Principle investigator for the project (Danube University Krems) Univ.-Prof. Dr. Viktoria Weber

Publications

Schildberger, A.; Roßmanith, E.; Weber, V.; Falkenhagen, D. (2010). Monitoring of endothelial cell activation in experimental sepsis with a two-step cell culture model. Innate Immunity, 16(5): 278-287

Buchacher, T. (2010). A Two-Step Cell Culture Model of Gram-Negative Sepsis: Effect of Nonspecific Mediator Adsorption on Endothelial Cell Activation. Diploma thesis

Schildberger, A. (2010). Testing of Specific Adsorbents on Endothelial Cell Activation in a Two-Step Cell Culture Model of Gram-Negative Sepsis. Doctor Thesis

Lectures

Modulation of the inflammatory mediator high mobility group box 1 protein with adsorbent polymers

4th ÖGMBT Annual Meeting 2012, Graz, Austria, 18/09/2012

Modulation of mediators from whole blood or monocytic cells stimulated with lipopolysaccharide reduces endothelial cell activation

32nd International Symposium on Intensive Care and Emergency Medicine - ISICEM, 20.-23.03.2012, Brussels, Belgium, 20/03/2012

Adsorbent-based modulation of inflammatory mediators dampens endothelial activation in a cell culture model for sepsis

8th Congress of the International Society for Apheresis, Vienna, Austria, 14.-17. September 2011, 15/09/2011

Modulation of endothelial cell activation with specific or selective adsorbents

2nd ÖGMBT Annual Meeting 2010, September 27-29, Vienna, Austria, 27/09/2010

Target finding in sepsis based on cell culture models

1st European Conference of Chemotherapy and Infection, Varna, Bulgaria, 6.-9.5 2010, 06/05/2010

Effect of Mediator Modulation with Specific or Selective Adsorbents on Endothelial Cell Activation in an Experimental Cell Culture Model of Sepsis

8th World Congress on Trauma, Shock, Inflammation and Sepsis; München, 9.-13.3.2010, 09/03/2010

Team

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