Application of a cell culture model for sepsis to investigate host cell responses to intracellular pathogens

Description

The aim of this project is to apply a cell culture model to reveal host cell responses provoked by intracellular pathogen infections and to copmpare these responses to those provoked by Gram-negative bacteria. In detail, a sepsis cell culture model based on monocytes and endothelial cells will be applied to investigate changes in biomarker secretion in order to correlate their concentration to the course of the disease. Further, different antibiotics will be applied and screened for their efficiency to treat infections with intracellular pathogens. A DNA microarray for intracellular as well as fastidious pathogens will be developed and an antibody microarray for biomarker detection will be applied. The project will result in a better understanding of intracellular infections. In addition, a diagnostic tool for the identification of intracellular pathogens and for monitoring the course of the disease will be developed.

Details

Duration 01/09/2010 - 31/08/2013
Funding Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program Life Science Krems
Department

Department for Biomedical Research

Center for Biomedical Technology

Principle investigator for the project (Danube University Krems) Univ.-Prof. Dr. Viktoria Weber

Lectures

Intracellular Chlamydophila pneumoniae versus extracellular pathogens in a cell culture model

4th ÖGMBT Annual Meeting 2012, Graz, Austria, 17/09/2012

Microarray-based detection of intracellular pathogens including automated result evaluation which enables parallel species identification of multiple infections

22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 31/03/2012

Investigation of host cell response to Chlamydia pneumonia using a cell culture model

3rd ÖGMBT Annual Meeting 2011, 28.-30.09.2011, Salzburg, Austria, 28/09/2011

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