Magnetic Pump

Description

In dynamic cell culturing a natural blood flow as it occurs in the human body would be preferred. Blood cells are exposed to an abnormal environment when taking a blood sample, transportation and particularly during pumping through a µ-slide for live-microscopy. Characteristic expressions of blood cells change due to strong pressure gradients and gravitational sedimentation. High shear stresses caused by pumping systems destroy a cells membrane. A gentle pulsatile pump integrated on a lab-on-chip device permits the constant recirculation of cell suspension, allow their culture under dynamic conditions and permit the analysis of cell-cell or cell-material interactions. Ferrofluidic pumping systems are limited due to plug leakage caused by high pressure gradients. Electromagnetic field simulations can be used to optimize nanoparticles closure between plug and channel surface. In order to obtain low cell damage with a high flow rate the particle damage index (PDI) is analysed. Velocity computation, shear stress calculation and optimal design are determined from a structured and automated optimization tool (HEEDS MDO). Obtained design parameters are used to fabricate a prototype cell gentle pump for cell imaging under [LSC13-024] Cell Gentle Pumping NFB - Antrag Abschnitt 1: Life Science Call 2013 - Aufruf zum Einreichen von Forschungsprojekten zum Themenkomplex Life Science dynamic conditions. Hemolysis tests of blood and cytotoxicity tests on cell lines ensure the biocompatibility of the proposed technology. ** This work is partially co-funded by the NÖ Forschungs- und Bildungsges.m.b.H. (NFB) within the Life Science Call. The authors are responsible for the contents of this publication.

Details

Duration 01/10/2014 - 30/09/2016
Funding Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program Life Science Call NFB
Department

Department for Integrated Sensor Systems

Center for Modeling and Simulating

Principle investigator for the project (Danube University Krems) Dipl.-Ing. Dr. Martin Brandl

Publications

Gusenbauer, M.; Mazza, G.; Posnicek, T.; Brandl, M.; Schrefl, T. (2018). Magnetically actuated circular displacement micropump. The International Journal of Advanced Manufacturing Technology, 95: 3575/https://doi.org/10.1007/s

Gusenbauer, M.; Schrefl, T. (2018). Simulation of magnetic particles in microfluidic channels. Journal of Magnetism and Magnetic Materials, Volume 446: 185-191

Gusenbauer, M.; Tothova, R.; Mazza, G.; Brandl, M.; Schrefl, T.; Jancigova, I.; Cimrak, I. (2018). Cell Damage Index as Computational Indicator for Blood Cell Activation and Damage. Artificial Organs, Volume 42, Issue 7: 746-755

Gusenbauer, M.; Mazza, G.; Brandl, M.; Schrefl, T. (2017). Sensing the blood cell damage in a magnetically actuated circular pump. IEEE, 2017 IEEE Sensors: 1-3

Gusenbauer, M.; Mazza, G.; Brandl, M.; Schrefl, T.; Tothova, R.; Jancigova, I.; Cimrak, I. (2016). Sensing platform for computational and experimental analysis of blood cell mechanical stress and activation in microfluidics. Procedia Engineering, 168: 1390–1393

Lectures

Sensing the blood cell damage in a magnetically actuated circular pump

IEEE Sensors 2017, 01/11/2017

Model-Based Design and Optimization of Microfluidic Systems for Gentle Cellular Perfusion

Sensor2017 Nürnberg, 31/05/2017

Keep the blood cells happy

2nd Workshop on Modelling of Biological Cells, Fluid Flow and Microfluidics, Vrátna, Slovakia, 06/02/2017

Rapid prototyping of miniature blood vessels

2nd Workshop on Modelling of Biological Cells, Fluid Flow and Microfluidics, Vrátna, Slovakia, 06/02/2017

Cell rheology in microfluidic perfusion: computational and experimental approach

MNE 2016, 21/09/2016

Sensing platform for theoretical and experimental analysis of blood cell mechanical stress and activation in microfluidics

Eurosensors 2016, 07/09/2016

Simulation of magnetic particles in blood flow to improve failsafe particle detection of microspheres based detoxification system

Particles 2015, 28/09/2015

Automated microfluidic optimization to reduce blood cell activation

CFD in Medicine and Biology II, 01/09/2015

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