Description
The consumption of food containing biogenic amines is reported to be responsible for many pharmacological effects (diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing) which lead to several types of foodborne disease, including histamine poisoning, mainly from ingestion of certain species of fish (scombroid poisoning), and tyramine toxicity (cheese reaction). Amines have also been implicated as the cause of toxicity to chicks and were also studied as carcinogenic precursors. Nevertheless, the occurrence of symptoms that result from such interactions remains hypothetical, because there are no acceptable clinical studies that demonstrate such reactions. One reason is the lack of reliable test methods. In BIOAMINA we, the Austrian Institute of Technology, Health and Environment Department and the Danube University Krems, Center of Integrated Sensor Systems will contribute to this issue developing a multiplex diagnostic tool that is capable of reliably and simultaneously measuring histamine, tyramine, putrescine and other biogenic amines in test food, serum and urine. For validation of the colorimetric enzyme-based assays and detection systems in clinically relevant samples an oral open food challenge study with healthy volunteers shall be conducted at the Karl Landsteiner Institute St. Poelten. ** This work is partially co-funded by the NÖ Forschungs- und Bildungsges.m.b.H. (NFB) within the Life Science Call.
Details
Duration | 01/10/2017 - 31/12/2021 |
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Funding | Bundesländer (inkl. deren Stiftungen und Einrichtungen) |
Program | nfb |
Department | |
Principle investigator for the project (University for Continuing Education Krems) | Dipl.-Ing. Dr. Martin Brandl |
Project members |
Lakshmi Devi Chakkarapani, PhD MSc
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Publications
Chakkarapani, L.D.; Brandl, M. (2021). Highly sensitive electrochemical detection of tyramine using a poly(toluidine blue)-modified carbon screen-printed electrode. IEEE Sensors Journal, 22: 1005613
Chakkarapani, L.D.; Brandl, M. (2021). Electrochemical Study of Poly(Azure A)-Film Manganese-Hexacyanoferrate-Complex modified Electrodes for Histamine Detection. In: Proceedings in 8th International Electronic Conference on Sensors and Applications: xx, MDPI, online
Chakkarapani, L. D.; Brandl, M. (2020). Carbon Screen-Printed Electrode Coated with Poly (Toluidine blue) as an Electrochemical Sensor for the Detection of Tyramine. MDPI Eng. Proc., 2/51: 10.3390/ecsa-7-08171
Wagner, L.-M.; Pilecky, M.; Mazza, G.; Preininger, C.; Brandl, M. (2018). Simulation and Performance Optimization of an Amperometric Histamine Detection System. MDPI Proceedings, 2018, 2: 853
Lectures
Insights into MnAl-C nano-twin defects by micromagnetic characterization
Extracting local switching fields in permanent magnets using machine learning
Influence of antiphase boundary of the MnAl t-phase on the energy product
Automated meshing of electron backscatter diffraction data and application to finite element micromagnetics