The aim of this project is to investigate endotoxin-neutralizing mechanisms in human whole blood. One focus is the influence of the anticoagulation on the effect of endotoxins and on endotoxin-neutralizing factors in whole blood. Furthermore, Host Defense Peptides will be isolated from human whole blood and their influence on the activity of endotoxins will be investigated.


Duration 01/03/2022 - 28/02/2025
Funding Bundesländer (inkl. deren Stiftungen und Einrichtungen)

Department for Biomedical Research

Center for Biomedical Technology

Principle investigator for the project (University for Continuing Education Krems) Assoz. Prof. Dr. Jens Hartmann


Cont, D.; Harm, S.; Schildboeck, C.; Kolm, C.; Kirschner, A.K.T.; Farnleitner, A.H.; Pilecky, M.; Zottl, J.; Hartmann, J.; Weber, V. (2024). The neutralizing effect of heparin on blood-derived antimicrobial compounds: impact on antibacterial activity and inflammatory response. Front Immunol, 15: 1373255

Project Manager

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