Description
The aim of this project is to investigate endotoxin-neutralizing mechanisms in human whole blood. One focus is the influence of the anticoagulation on the effect of endotoxins and on endotoxin-neutralizing factors in whole blood. Furthermore, Host Defense Peptides will be isolated from human whole blood and their influence on the activity of endotoxins will be investigated.
Details
| Duration | 01/03/2022 - 28/02/2025 |
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| Funding | Bundesländer (inkl. deren Stiftungen und Einrichtungen) |
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| Department | |
| Principle investigator for the project (University for Continuing Education Krems) | Assoz. Prof. Dr. Jens Hartmann |
Publications
Cont, D.; Harm, S.; Schildboeck, C.; Kolm, C.; Kirschner, A.K.T.; Farnleitner, A.H.; Pilecky, M.; Zottl, J.; Hartmann, J.; Weber, V. (2024). The neutralizing effect of heparin on blood-derived antimicrobial compounds: impact on antibacterial activity and inflammatory response. Front Immunol, 15: 1373255
