Alexander Otahal

Alexander Otahal, PhD MSc

Center for Regenerative Medicine

Projects (Extract Research Database)

Running projects

Regulating functional meniscus tissue regeneration by 3D-bioprinted complex geometrically precise hybrid scaffolds

Duration: 01/01/2022–31/12/2024
Principle investigator for the project (University for Continuing Education Krems): Alexander Otahal
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)

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Completed projects

The Role of microvesicles from blood derived products in osteoarthritis

Duration: 01/01/2018–29/02/2020
Principle investigator for the project (University for Continuing Education Krems): Andrea De Luna
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program: Technologieförderung NÖ

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Publications (Extract Research Database)

Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224

Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823

De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050

Lectures (Extract Research Database)

Extracellular vesicles in blood derived products

ICRS Word Congress, 12/01/2023

Polybrene enhances uptake of extracellular vesicles derived from Hoffa mesenchymal stromal cells into primary osteoarthritic chondrocytes

Small New World Joint Meeting of ASEV & GSEV, 29/10/2022

Extracellular vesicles from blood derived products for cartilage repair

ASEV/GSEV Joint Meeting, 28/10/2022

Functional repertoire of EV-associated miRNA profiles from blood-derived products

48th Annual ESAO Congress, 10/09/2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair? - a status report

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 27/04/2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair

ICRS Word Congress, 14/04/2022

Association of regenerative capacity of blood EVs on primary osteoarthritic chondrocytes with EV associated miRNAs

ICRS 2022 World Congress Berlin, 14/04/2022

Extracellular vesicle-associated miRNA cargo could explain regenerative capacities of blood-derived extracellular vesicles on primary osteoarthritic chondrocytes

OARSI 2022 World Congress, 08/04/2022

Chondroprotective and anti-inflammatory effects mediated by extracellular vesicles from plasma- and serumbased blood-derived products for osteoarthritis therapy

6th world congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS2021), 17/11/2021

Regenerative capacity of blood-derived EVs on primary osteoarthritic chondrocytes coincides with the EVassociated miRNA functional repertoire

Austrian Society for Extracellular Vesicles Young Scientist Meeting, 15/10/2021

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