Alexander Otahal

Alexander Otahal, PhD MSc

Center for Regenerative Medicine

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Projects (Extract Research Database)

Running projects

Biodistribution of extracellular vesicles between chondral and synovial tissue constructs in a microfluidic organ-on-chip system

Duration: 01/05/2024–30/11/2024
Principle investigator for the project (University for Continuing Education Krems): Alexander Otahal
Funding: FWF

Regulating functional meniscus tissue regeneration by 3D-bioprinted complex geometrically precise hybrid scaffolds

Duration: 01/01/2022–31/12/2024
Principle investigator for the project (University for Continuing Education Krems): Alexander Otahal
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)

Completed projects

The Role of microvesicles from blood derived products in osteoarthritis

Duration: 01/01/2018–29/02/2020
Principle investigator for the project (University for Continuing Education Krems): Andrea De Luna
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program: Technologieförderung NÖ

Publications (Extract Research Database)

Otahal, A.; Kramer, K.; Neubauer, M.; Gulová, S.; Lacza, Z.; Nehrer, S.; De Luna, A. (2024). Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production. Stem Cell Research and Therapy, 15: https://doi.org/10.1186/s13287-024-03681-9

Otahal, A.; Neubauer, M.; Nehrer, S. (2024). Blood Products and Stem Cells in Osteoarthritis Therapy. Z Orthop Unfall, 162(05): 533-548

Pasztorek, M.; Fischer, J.; Otahal, A.; de Luna, A.; Nehrer, S.; Rosser, J. (2024). Exploring Osteoarthritis Dynamics: Patient-Specific Cartilage Samples in an Organ-on-a-Chip Model. Cartilage, Sept: 10

Moser, L.B.; Bauer, C.; Otahal, A.; Kern, D.; Dammerer, D.; Zantop, T.; Nehrer, S. (2023). Mincing bovine articular cartilage with commercially available shavers reduces the via-bility of chondrocytes compared to scalpel mincing. J Exp Orthop., 10(1): doi: 10.1186/s40634-023-00661-5.

Neubauer, M.; Otahal, A.; Kuten, S.; Sherman, S.L.; Moser, L.; Kramer K.; DeLuna, A.; Neugebauer, J.; Dammerer, D.; Muellner, T.; Nehrer, S. (2023). Infra-patellar fat pad-derived mesenchymal stem cells maintain their chondrogenic dif-ferentiation potential after arthroscopic harvest with blood-product supplementation. Int Orthop., 30: doi: 10.1007/s00264-023-05930-7

Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America

Otahal, A (2023). Extrazelluläre Vesikel, die Botenstoffe der Regeneration. JATROS - Orthopädie & Traumatologie Rheumatologie, 2/2023: 20, Universimed

Otahal, A.; Tischer, T.; De Luna, A.; Nehrer, S. (2023). Plättchenreiches Plasma und andere Blutprodukte – neue Forschungsaspekte zur Wirkung von Blutderivaten und klinische Ergebnisse bei Gonarthrose. Knie Journal, 5(3): 142–149, Springer

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224

Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823

De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050

Lectures (Extract Research Database)

Extrazelluläre Vesikel - Die Botenstoffe der Regeneration?

Wissenschaftsbotschafter, 31/01/2024

Hoffa-derived MSC extracellular vesicles in osteoarthritis – friend or foe?

LBG Meeting Innovation in Health Sciences 2023, 02/11/2023

Hoffa-derived MSCs primed with IL1ß in bioreactor culture yield extracellular vesicles hindering chondrocyte recovery

17th World Congress ICRS 2023, 11/09/2023

Hoffa-derived MSCs primed with IL1ß in bioreactor culture yield extracellular vesicles hindering chondrocyte recovery

Small New World 2.0, 04/09/2023

Hoffa MSC-Derived Extracellular Vesicles in Osteoarthritis – Friend or Foe?

19th Life Science Meeting 2023, 23/05/2023

Extracellular vesicles from Hoffa Fat Pad MSCs favor the osteoarthritic phenotype of chondrocytes

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 03/05/2023

Culture of Hoffa-derived MSCs in vertical wheel bioreactor for EV production in comparison to static 2D culture

Annual meeting of the Austrian Cluster for Tissue Regeneration, 03/05/2023

Extracellular vesicles in blood derived products

ICRS World Congress, 12/04/2023

Polybrene enhances uptake of extracellular vesicles derived from Hoffa mesenchymal stromal cells into primary osteoarthritic chondrocytes

Small New World Joint Meeting of ASEV & GSEV, 29/10/2022

Extracellular vesicles from blood derived products for cartilage repair

ASEV/GSEV Joint Meeting, 28/10/2022

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