Projekte (Auszug Forschungs­datenbank)

Laufende Projekte

Biodistribution of extracellular vesicles between chondral and synovial tissue constructs in a microfluidic organ-on-chip system

Projektzeitraum: 01.05.2024–30.11.2024
Projektverantwortung (Universität für Weiterbildung Krems): Alexander Otahal
Fördergeber: FWF

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Regulating functional meniscus tissue regeneration by 3D-bioprinted complex geometrically precise hybrid scaffolds

Projektzeitraum: 01.01.2022–31.12.2024
Projektverantwortung (Universität für Weiterbildung Krems): Alexander Otahal
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)

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Abgeschlossene Projekte

The Role of Microvesicles from Blood Derived Products in Osteoarthritis

Projektzeitraum: 01.01.2018–29.02.2020
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Technologieförderung NÖ

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Publikationen (Auszug Forschungs­datenbank)

Otahal, A.; Kramer, K.; Neubauer, M.; Gulová, S.; Lacza, Z.; Nehrer, S.; De Luna, A. (2024). Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production. Stem Cell Research and Therapy, 15: https://doi.org/10.1186/s13287-024-03681-9

Moser, L.B.; Bauer, C.; Otahal, A.; Kern, D.; Dammerer, D.; Zantop, T.; Nehrer, S. (2023). Mincing bovine articular cartilage with commercially available shavers reduces the via-bility of chondrocytes compared to scalpel mincing. J Exp Orthop., 10(1): doi: 10.1186/s40634-023-00661-5.

Neubauer, M.; Otahal, A.; Kuten, S.; Sherman, S.L.; Moser, L.; Kramer K.; DeLuna, A.; Neugebauer, J.; Dammerer, D.; Muellner, T.; Nehrer, S. (2023). Infra-patellar fat pad-derived mesenchymal stem cells maintain their chondrogenic dif-ferentiation potential after arthroscopic harvest with blood-product supplementation. Int Orthop., 30: doi: 10.1007/s00264-023-05930-7

Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America

Otahal, A (2023). Extrazelluläre Vesikel, die Botenstoffe der Regeneration. JATROS - Orthopädie & Traumatologie Rheumatologie, 2/2023: 20, Universimed

Otahal, A.; Tischer, T.; De Luna, A.; Nehrer, S. (2023). Plättchenreiches Plasma und andere Blutprodukte – neue Forschungsaspekte zur Wirkung von Blutderivaten und klinische Ergebnisse bei Gonarthrose. Knie Journal, 5(3): 142–149, Springer

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224

Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823

De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050

Vorträge (Auszug Forschungs­datenbank)

Extrazelluläre Vesikel - Die Botenstoffe der Regeneration?

Wissenschaftsbotschafter, 31.01.2024

Hoffa-derived MSC extracellular vesicles in osteoarthritis – friend or foe?

LBG Meeting Innovation in Health Sciences 2023, 02.11.2023

Hoffa-derived MSCs primed with IL1ß in bioreactor culture yield extracellular vesicles hindering chondrocyte recovery

17th World Congress ICRS 2023, 11.09.2023

Hoffa-derived MSCs primed with IL1ß in bioreactor culture yield extracellular vesicles hindering chondrocyte recovery

Small New World 2.0, 04.09.2023

Hoffa MSC-Derived Extracellular Vesicles in Osteoarthritis – Friend or Foe?

19th Life Science Meeting 2023, 23.05.2023

Extracellular vesicles from Hoffa Fat Pad MSCs favor the osteoarthritic phenotype of chondrocytes

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 03.05.2023

Culture of Hoffa-derived MSCs in vertical wheel bioreactor for EV production in comparison to static 2D culture

Annual meeting of the Austrian Cluster for Tissue Regeneration, 03.05.2023

Extracellular vesicles in blood derived products

ICRS World Congress, 12.04.2023

Polybrene enhances uptake of extracellular vesicles derived from Hoffa mesenchymal stromal cells into primary osteoarthritic chondrocytes

Small New World Joint Meeting of ASEV & GSEV, 29.10.2022

Extracellular vesicles from blood derived products for cartilage repair

ASEV/GSEV Joint Meeting, 28.10.2022

Functional repertoire of EV-associated miRNA profiles from blood-derived products

48th Annual ESAO Congress, 10.09.2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair? - a status report

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 27.04.2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair

ICRS World Congress, 14.04.2022

Association of regenerative capacity of blood EVs on primary osteoarthritic chondrocytes with EV associated miRNAs

ICRS 2022 World Congress Berlin, 14.04.2022

Extracellular vesicle-associated miRNA cargo could explain regenerative capacities of blood-derived extracellular vesicles on primary osteoarthritic chondrocytes

OARSI 2022 World Congress, 08.04.2022

Chondroprotective and anti-inflammatory effects mediated by extracellular vesicles from plasma- and serumbased blood-derived products for osteoarthritis therapy

6th world congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS2021), 17.11.2021

Regenerative capacity of blood-derived EVs on primary osteoarthritic chondrocytes coincides with the EVassociated miRNA functional repertoire

Austrian Society for Extracellular Vesicles Young Scientist Meeting, 15.10.2021

Blood-product derived extracellular vesicles in osteoarthritis

Austrian Cluster for Tissue Engineering Meeting, 30.08.2021

Regenerative capacity of blood derived EVs on primary osteoarthritic chondrocytes coincides with the EV associated miRNA functional repertoire

Annual meeting of the International society for extracellular vesicles (ISEV2021), 18.05.2021

miRNAs enriched in extracellular vesicles in plasma and serum based autologous blood derived products for osteoarthritis therapy

YIRM, Krems, Österreich, 13.12.2019

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