Alexander Otahal, PhD MSc
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alexander.otahal@donau-uni.ac.at
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+43 2732 893-5415
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Zum Kontaktformular
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Campus Krems, Trakt C, 3. Stock, 3.14
- Universität für Weiterbildung Krems
- Zentrum für Regenerative Medizin
- Dr.-Karl-Dorrek-Straße 30
- 3500 Krems
- Österreich
Projekte (Auszug Forschungsdatenbank)
Laufende Projekte
Projektzeitraum: 01.05.2024–30.04.2025
Projektverantwortung (Universität für Weiterbildung Krems): Alexander Otahal
Fördergeber: FWF
Projektzeitraum: 01.01.2022–31.12.2024
Projektverantwortung (Universität für Weiterbildung Krems): Alexander Otahal
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Abgeschlossene Projekte
The Role of Microvesicles from Blood Derived Products in Osteoarthritis
Projektzeitraum: 01.01.2018–29.02.2020
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Technologieförderung NÖ
Publikationen (Auszug Forschungsdatenbank)
Moser, Anna-Christina; Fritz, Jennifer; Kesselring, Andreas; Schüssler, Florian; Otahal, Alexander; Nehrer, Stefan (2025). Biomechanical testing of virtual meniscus implants made from a bi-phasic silk fibroin-based hydrogel and polyurethane via finite element analysis. Journal of the Mechanical Behavior of Biomedical Materials, 162: 106830
Otahal, A.; Kramer, K.; Neubauer, M.; Gulová, S.; Lacza, Z.; Nehrer, S.; De Luna, A. (2024). Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production. Stem Cell Research and Therapy, 15: https://doi.org/10.1186/s13287-024-03681-9
Otahal, A.; Neubauer, M.; Nehrer, S. (2024). Blood Products and Stem Cells in Osteoarthritis Therapy. Z Orthop Unfall, 162(05): 533-548
Pasztorek, M.; Fischer, J.; Otahal, A.; de Luna, A.; Nehrer, S.; Rosser, J. (2024). Exploring Osteoarthritis Dynamics: Patient-Specific Cartilage Samples in an Organ-on-a-Chip Model. Cartilage, Sept: 10
Moser, L.B.; Bauer, C.; Otahal, A.; Kern, D.; Dammerer, D.; Zantop, T.; Nehrer, S. (2023). Mincing bovine articular cartilage with commercially available shavers reduces the via-bility of chondrocytes compared to scalpel mincing. J Exp Orthop., 10(1): doi: 10.1186/s40634-023-00661-5.
Neubauer, M.; Otahal, A.; Kuten, S.; Sherman, S.L.; Moser, L.; Kramer K.; DeLuna, A.; Neugebauer, J.; Dammerer, D.; Muellner, T.; Nehrer, S. (2023). Infra-patellar fat pad-derived mesenchymal stem cells maintain their chondrogenic dif-ferentiation potential after arthroscopic harvest with blood-product supplementation. Int Orthop., 30: doi: 10.1007/s00264-023-05930-7
Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America
Otahal, A (2023). Extrazelluläre Vesikel, die Botenstoffe der Regeneration. JATROS - Orthopädie & Traumatologie Rheumatologie, 2/2023: 20, Universimed
Otahal, A.; Tischer, T.; De Luna, A.; Nehrer, S. (2023). Plättchenreiches Plasma und andere Blutprodukte – neue Forschungsaspekte zur Wirkung von Blutderivaten und klinische Ergebnisse bei Gonarthrose. Knie Journal, 5(3): 142–149, Springer
Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224
Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823
De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386
Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050
Vorträge (Auszug Forschungsdatenbank)
Extrazelluläre Vesikel als Boten der Regeneration
Wissenschaftsbotschafter, 17.01.2025
EVs are the way
7th ICRS Summit: From molecule to implant, 25.09.2024
Paving the way for cartilage regeneration - Introducing research at the Center for Regenerative Medicine
ASEV-CzeSEV Joint Meeting On Extracellular Vesicles, 16.09.2024
Blutprodukte und Zelltherapien: Grundlagenwissenschaft zum Wirkmechanismus
AGA Denkfabrik, 05.07.2024
Larger-scale enrichment of extracellular vesicles of Hoffa-derived adipose MSCs from dynamic microcarrier suspension culture in vertical wheel bioreactor
OARSI World Congress, 18.04.2024
Novel Injectable Silk-based Hydrogel For Cartilage Regeneration
OARSI World Congress, 18.04.2024
Extrazelluläre Vesikel - Die Botenstoffe der Regeneration?
Wissenschaftsbotschafter, 31.01.2024
Extrazelluläre Vesikel als Boten der Regeneration
Wissenschaftsbotschafter, 23.01.2024
Hoffa-derived MSC extracellular vesicles in osteoarthritis – friend or foe?
LBG Meeting Innovation in Health Sciences 2023, 02.11.2023
Hoffa-derived MSCs primed with IL1ß in bioreactor culture yield extracellular vesicles hindering chondrocyte recovery
17th World Congress ICRS 2023, 11.09.2023
Hoffa-derived MSCs primed with IL1ß in bioreactor culture yield extracellular vesicles hindering chondrocyte recovery
Small New World 2.0, 04.09.2023
Hoffa MSC-Derived Extracellular Vesicles in Osteoarthritis – Friend or Foe?
19th Life Science Meeting 2023, 23.05.2023
Extracellular vesicles from Hoffa Fat Pad MSCs favor the osteoarthritic phenotype of chondrocytes
Annual Meeting of the Austrian Cluster of Tissue Regeneration, 03.05.2023
Culture of Hoffa-derived MSCs in vertical wheel bioreactor for EV production in comparison to static 2D culture
Annual meeting of the Austrian Cluster for Tissue Regeneration, 03.05.2023
Extracellular vesicles in blood derived products
ICRS World Congress, 12.04.2023
Polybrene enhances uptake of extracellular vesicles derived from Hoffa mesenchymal stromal cells into primary osteoarthritic chondrocytes
Small New World Joint Meeting of ASEV & GSEV, 29.10.2022
Extracellular vesicles from blood derived products for cartilage repair
ASEV/GSEV Joint Meeting, 28.10.2022
Functional repertoire of EV-associated miRNA profiles from blood-derived products
48th Annual ESAO Congress, 10.09.2022
Extracellular Vesicles in Blood-Derived Products for Cartilage Repair? - a status report
Annual Meeting of the Austrian Cluster of Tissue Regeneration, 27.04.2022
Association of regenerative capacity of blood EVs on primary osteoarthritic chondrocytes with EV associated miRNAs
ICRS 2022 World Congress Berlin, 14.04.2022
