Sepsis is a life-threatening organ dysfunction resulting from a severe systemic inflammation caused by an infection. Worldwide, approximately 31.5 million sepsis cases occur annually with a mortality of up to 50% in septic shock. The development of supportive sepsis therapies remains a major challenge due to the complex pathogenesis of this inflammatory syndrome and due to the vast heterogeneity of septic patients. The aims of this project are (i) to improve the diagnostic potential of sepsis by establishing new biomarkers for systemic infections, in particular, the role of extracellular vesicles; (ii) to investigate the central role of the endothelium in sepsis; and (iii) to study the effect of inflammatory mediator modulation by extracorporeal adsorption therapies in sepsis patients.


Duration 01/01/2020 - 31/12/2025
Funding Bundesländer (inkl. deren Stiftungen und Einrichtungen)

Department for Biomedical Research

Center for Biomedical Technology

Principle investigator for the project (University for Continuing Education Krems) Tanja Eichhorn, PhD MSc

Project Manager

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