Osteoarthritis is among the most important pathologies in humanity and leads to immobility and pain. The current trend focuses on replacing total joint replacements in patients by less aggressive partial options with the aim of boosting patient recovery and increase their quality of life. Although this surgery is smaller and partial replacement concepts allow faster rehabilitation, the rates of failures are significantly higher than after total joint replacement. This is related to the progressive degeneration of the preserved area of joint surface that remains after partial replacement or loosening or biomechanic insufficiency of the implant. However, there is little research done on the tribological behaviour of articular cartilage and adjacent metal implants with respect to the influence of wear on the remaining cartilage or inflammatory reaction of the existing cartilage on the residing implant or other phenomena that might occur like corrosion. Within this context, the present work aims to assess the mechanical and physiological parameters that determine the lifetime of partial replacement technology. The project will address the role of bio-tribocorrision on partial replacements during sliding contact against cartilage due to the combined effect of mechanical wear and corrosion, with emphasis on Cobalt ion release. Further, chondrocyte viability at the interface between the cobalt-chrome-molybdenum metal surface and the cartilage will be correlated with biomechanical and physiological parameters. Complementary investigations will be performed on chondrocyte cells in-vitro with the aim of determining critical loading parameters for chondrocyte viability. The results will serve as basis for evaluating the effects of partial implant on cartilage biology as well as synovial fluid in order to optimize the concept of partial joint replacements. This project is funded by the NFB (NÖ Forschungs- und Bildungsges.m.b.H.).

Cooperation partner



Duration 01/01/2017 - 30/06/2020
Funding Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program Life Science Call NFB

Department for Health Sciences, Medicine and Research

Center for Regenerative Medicine

Principle investigator for the project (University for Continuing Education Krems) Dr. Christoph Stotter
Project members
Mag. Eugenia-Paulina Niculescu-Morzsa



Stotter, C.; Bauer, C.; Simlinger, B.; Ripoll, MR.; Franek, F.; Klestil, T.; Nehrer, S. (2020). Biotribological testing and analysis of articular cartilage sliding against metal for implants. Journal of Visualized Experiments, Issue 159: ka

Bauer, C.; Stotter, C.; Jeyakumar, V.; Niculescu-Morzsa, E.; Simlinger, B.; Rodriguez Ripoll, M.; Klestil, T.; Franek, F.; Nehrer, S. (2019). Concentration-Dependent Effects of Cobalt and Chromium Ions on Osteoarthritic Chondrocytes. Cartilage, Epub ahead of print: 10.1177/1947603519889389

Stojanovic, B.; Bauer, C.; Stotter, C.; Klestil, T.; Nehrer, S.; Franek, F.; Rodriguez Ripoll, M. (2019). Tribocorrosion of a CoCrMo alloy sliding against articular cartilage and impact of metal ion release on chondrocytes. Acta biomaterialia, Volume 94: 597-609

Stotter, C.; Stojanovic, B.; Bauer, C.; Rodriguez Ripoll, M.; Franek, F.; Klestil, T.; Nehrer, S. (2019). Effects of Loading Conditions on Articular Cartilage in a Metal-on-Cartilage Pairing. Journal of Orthopaedic Research, Epub ahead of print: 10.1002/jor.24426

Klestil, T.; Röder, C.; Stotter, C.; Winkler, B.; Nehrer, S.; Lutz, M.; Klerings, I.; Wagner, G.; Gartlehner, G.; Nussbaumer-Streit, B. (2017). Immediate versus delayed surgery for hip fractures in the elderly patients: a protocol for a systematic review and meta-analysis. Systematic Reviews, 6(1): doi: 10.1186/s13643-017-0559-7


Bio-tribology and cartilage repair

7th Congress of Indian Cartilage Society, 30/10/2021

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