Assoz. Prof. Mag. Andrea De Luna, PhD

Ass.-Prof. - Zentrum für Regenerative Medizin

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Projekte (Auszug Forschungs­datenbank)

Abgeschlossene Projekte

Extracellular vesicles from Hoffa´s fat pad- a new strategy for cartilage regeneration

Projektzeitraum: 01.03.2020–28.02.2023
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Life Science Call NFB

The Role of Microvesicles from Blood Derived Products in Osteoarthritis

Projektzeitraum: 01.01.2018–29.02.2020
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Technologieförderung NÖ

Durchführbarkeitsstudie des Serumisolators hypACT

Projektzeitraum: 02.05.2017–31.05.2017
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Unternehmen
Förderprogramm: ---

Identification of novel treatment options for osteoarthritis

Projektzeitraum: 05.11.2012–30.04.2016
Projektverantwortung (Universität für Weiterbildung Krems): Stefan Nehrer
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Life Science Call NFB

Publikationen (Auszug Forschungs­datenbank)

Otahal, A.; Kramer, K.; Neubauer, M.; Gulová, S.; Lacza, Z.; Nehrer, S.; De Luna, A. (2024). Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production. Stem Cell Research and Therapy, 15: https://doi.org/10.1186/s13287-024-03681-9

Neubauer, M.; Otahal, A.; Kuten, S.; Sherman, S.L.; Moser, L.; Kramer K.; DeLuna, A.; Neugebauer, J.; Dammerer, D.; Muellner, T.; Nehrer, S. (2023). Infra-patellar fat pad-derived mesenchymal stem cells maintain their chondrogenic dif-ferentiation potential after arthroscopic harvest with blood-product supplementation. Int Orthop., 30: doi: 10.1007/s00264-023-05930-7

Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America

Otahal, A.; Tischer, T.; De Luna, A.; Nehrer, S. (2023). Plättchenreiches Plasma und andere Blutprodukte – neue Forschungsaspekte zur Wirkung von Blutderivaten und klinische Ergebnisse bei Gonarthrose. Knie Journal, 5(3): 142–149, Springer

Kuten-Pella, O.; De Luna, A.; Kramer, K.; Neubauer, M.; Nehrer, S.; Lacza, Z. (2021). Regenerative Potential of Blood-Derived Products in 3D Osteoarthritic Chondrocyte Culture System. Curr Issues Mol Biol, 43(2): 665-675

Olmos Calvo, I.; Kuten-Pella, O.; Kramer, K.; Madár, À.; Takács, S.; Kardos, D.; Simon, D.; Erdö-Bonyár, S.; Berki, T.; De Luna, A.; Nehrer, S.; Lacza Z. (2021). Optimization of Lyophilized Hyperacute Serum (HAS) as a Regenerative Therapeutic in Osteoarthritis. Int J Mol Sci, 22 (14): 7496

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224

Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823

De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050

Kuten, O.; Simon, M.; Hornyák, I.; De Luna-Preitschopf, A.; Nehrer, S.; Lacza, Z. (2018). The Effects of Hyperacute Serum on Adipogenesis and Cell Proliferation of Mesenchymal Stromal Cells. Tissue Engineering Part A, Vol. 24, No. 11-12: doi: 10.1089/ten.TEA.2017.0384

De Luna-Preitschopf, A.; Zwickl, H.; Nehrer, S.; Hengstschläger, M.; Mikula, M. (2017). Rapamycin Maintains the Chondrocytic Phenotype and Interferes with Inflammatory Cytokine Induced Processes. International Journal of Molecular Sciences, 18(7): doi:10.3390/ijms18071494

Preitschopf, A.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Zwickl, H.; Rosner, M.; Joó, J.G.; Nehrer, S; Hengstschläger, M; Mikula, M. (2016). Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells. Stem Cells Translational Medicine: 580-90

Schörghofer, D.; Kinslechner, K.; Preitschopf, A.; Schütz, B.; Röhrl, C.; Hengstschläger, M.; Stangl, H.; Mikula, M. (2015). The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence . Reprod Biol Endocrinol, Vol. 13, No. 88

Üstün, S.; Lassnig, C.; Preitschopf, A.; Mikula, M.; Müller, M.; Hengstschläger, M.; Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transplantation Immunology: 45-50

Üstün, S.; Lassnig, C.; Preitschopf, A.; Mikula, M.; Müller, M.; Hengstschläger, M.; Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transpl Immunol.

Preitschopf, A.; Zwickl, H.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Rosner, M.; Joo, G.J.; Hengstschläger, M.; Nehrer, S.; Mikula, M. (2015). Rapamycin enhances Sox9 Expression during Chondrogenic Differentiation of Amniotic Fluid Stem Cells. Tissue Engineering Part A, September 2015, Volume 21, Supplement 1: 192

Preitschopf, A.; Zwickl, H.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Rosner, M.; Joó, J.; Hengstschläger, M.; Nehrer, S.; Mikula, M. (2015). Rapamycin enhances SOX9 expression during chondrogenic differentiation of amniotic fluid stem cells. Tissue Engineering Part A: 192-93

Preitschopf, A.; Li, K.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Thi Thanh Pham, H.; Rosner, M.; Joo, G.; Röhrl, C.; Weichhart, T.; Stangl, H.; Lubec, G.; Hengstschläger, M.; Mikula, M. (2014). mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression. Plos One

Preitschopf, A.; Busch, J.; Zwickl, H.; Nehrer, S.; Hengstschläger, M.; Mikula, M. (2014). Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects. In: Perinatal Stem Cells: 87-98, Springer Verlag

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Vorträge (Auszug Forschungs­datenbank)

Extracellular vesicles from Hoffa Fat Pad derived MSC - silver linings for cartilage repair?

Jahrestagung des Vienna Center for Engineering in Medicine, 13.12.2023

Extracellular vesicles from Hoffa Fat Pad derived mesenchymal stem cells – friends or foe?

Webinar of the Italian Society of Stem Cells, 04.07.2023

Extracellular vesicles from Hoffa Fat Pad MSCs favor the osteoarthritic phenotype of chondrocytes

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 03.05.2023

Extracellular vesicles in blood derived products

ICRS World Congress, 12.04.2023

Isolation and culture of Hoffa-derived adipose MSCs for extracellular vesicle production in a vertical wheel bioreactorÖGMBT W

ÖGMBT Workshop „Advanced Cell Culture Technologies", 17.03.2023

Extracellular vesicles from blood derived products for cartilage repair

ASEV/GSEV Joint Meeting, 28.10.2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair? - a status report

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 27.04.2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair

ICRS World Congress, 14.04.2022

Effects of extracellular vesicles from blood derivatives on osteoarthritic chondrocytes

ASEV/GSEV Joint Meeting, Freising, Deutschland, 28.11.2019

Anti-coagulation influences properties of extracellular vesicles isolated from autologous blood derived products used for cartilage repair

World Congress of the International cartilage repair and joint preservation society, Vancouver, Kanada, 08.10.2019

Current Trends in Regenerative Medicine and Tissue Engineering

BioArt Workshop, Krems, Österreich, 03.06.2019

Coagulation influences properties of extracellular vesicles isolated from autologous blood derived products

TERMIS EU Chapter, Rhodos, Griechenland, 28.05.2019

Blood derived products contain extracellular vesicles with distinct biological properties for regenerative approaches

Word Congress of the International Society of Extracellular Vesicles (ISEV), Kyoto, Japan, 25.04.2019

Die Rolle von extrazellulärem Vesikeln aus Blutprodukten in der Osteoarthrose

Technopol Frühstück, Krems,Österreich, 20.03.2019

Different production technology of blood derived products influences differentiation pathway of various cell populations

World Congress of the International Society of Tissue Engineering and Regenerative Medicine (TERMIS), Kyoto, Japan, 07.09.2018

Different production technology of blood derived products influences differentiation pathway of various cell populations

Gordon Research Conference on Extracellular Vesicles, Newry, USA, 21.08.2018

Different production technology of blood derived products influences differentiation pathway of various cell populations

14. World congress of the International cartilage repair society (ICRS) , Macau, China, 12.04.2018

Inhibierung des mTORC1 Signalweges erhält den chondrogenen Phönotyp von OA Chondrozyten

32. Jahreskongress der GOTS, 24.06.2017

Rapamycin preserves the chondrogenic phenotype and supresses cartilage degrading and inflammatory processes in Osteoarthritis

OARSI 2017 World Congress, 28.04.2017

Strategies for Cartilage Regeneration

14. International Life Science Meeting Krems, 05.04.2017

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