Ass.-Prof. Mag. Andrea De Luna, PhD
- andrea.de-luna@donau-uni.ac.at
- +43 2732 893-5504
- Zum Kontaktformular
- Campus Krems, Trakt C, 3. Stock, C 3.14
- Universität für Weiterbildung Krems
- Zentrum für Regenerative Medizin
- Dr.-Karl-Dorrek-Straße 30
- 3500 Krems
- Österreich
Projekte (Auszug Forschungsdatenbank)
Abgeschlossene Projekte
Extracellular vesicles from Hoffa´s fat pad- a new strategy for cartilage regeneration
Projektzeitraum: 01.03.2020–28.02.2023
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Life Science Call NFB
The Role of Microvesicles from Blood Derived Products in Osteoarthritis
Projektzeitraum: 01.01.2018–29.02.2020
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Technologieförderung NÖ
Durchführbarkeitsstudie des Serumisolators hypACT
Projektzeitraum: 02.05.2017–31.05.2017
Projektverantwortung (Universität für Weiterbildung Krems): Andrea De Luna
Fördergeber: Unternehmen
Förderprogramm: ---
Identification of novel treatment options for osteoarthritis
Projektzeitraum: 05.11.2012–30.04.2016
Projektverantwortung (Universität für Weiterbildung Krems): Stefan Nehrer
Fördergeber: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Förderprogramm: Life Science Call NFB
Publikationen (Auszug Forschungsdatenbank)
Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America
Kuten-Pella, O.; De Luna, A.; Kramer, K.; Neubauer, M.; Nehrer, S.; Lacza, Z. (2021). Regenerative Potential of Blood-Derived Products in 3D Osteoarthritic Chondrocyte Culture System. Curr Issues Mol Biol, 43(2): 665-675
Olmos Calvo, I.; Kuten-Pella, O.; Kramer, K.; Madár, À.; Takács, S.; Kardos, D.; Simon, D.; Erdö-Bonyár, S.; Berki, T.; De Luna, A.; Nehrer, S.; Lacza Z. (2021). Optimization of Lyophilized Hyperacute Serum (HAS) as a Regenerative Therapeutic in Osteoarthritis. Int J Mol Sci, 22 (14): 7496
Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224
Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823
De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386
Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050
Kuten, O.; Simon, M.; Hornyák, I.; De Luna-Preitschopf, A.; Nehrer, S.; Lacza, Z. (2018). The Effects of Hyperacute Serum on Adipogenesis and Cell Proliferation of Mesenchymal Stromal Cells. Tissue Engineering Part A, Vol. 24, No. 11-12: doi: 10.1089/ten.TEA.2017.0384
De Luna-Preitschopf, A.; Zwickl, H.; Nehrer, S.; Hengstschläger, M.; Mikula, M. (2017). Rapamycin Maintains the Chondrocytic Phenotype and Interferes with Inflammatory Cytokine Induced Processes. International Journal of Molecular Sciences, 18(7): doi:10.3390/ijms18071494
Preitschopf, A.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Zwickl, H.; Rosner, M.; Joó, J.G.; Nehrer, S; Hengstschläger, M; Mikula, M. (2016). Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells. Stem Cells Translational Medicine: 580-90
Schörghofer, D.; Kinslechner, K.; Preitschopf, A.; Schütz, B.; Röhrl, C.; Hengstschläger, M.; Stangl, H.; Mikula, M. (2015). The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence . Reprod Biol Endocrinol, Vol. 13, No. 88
Üstün, S.; Lassnig, C.; Preitschopf, A.; Mikula, M.; Müller, M.; Hengstschläger, M.; Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transplantation Immunology: 45-50
Üstün, S.; Lassnig, C.; Preitschopf, A.; Mikula, M.; Müller, M.; Hengstschläger, M.; Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transpl Immunol.
Preitschopf, A.; Zwickl, H.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Rosner, M.; Joo, G.J.; Hengstschläger, M.; Nehrer, S.; Mikula, M. (2015). Rapamycin enhances Sox9 Expression during Chondrogenic Differentiation of Amniotic Fluid Stem Cells. Tissue Engineering Part A, September 2015, Volume 21, Supplement 1: 192
Preitschopf, A.; Zwickl, H.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Rosner, M.; Joó, J.; Hengstschläger, M.; Nehrer, S.; Mikula, M. (2015). Rapamycin enhances SOX9 expression during chondrogenic differentiation of amniotic fluid stem cells. Tissue Engineering Part A: 192-93
Preitschopf, A.; Li, K.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Thi Thanh Pham, H.; Rosner, M.; Joo, G.; Röhrl, C.; Weichhart, T.; Stangl, H.; Lubec, G.; Hengstschläger, M.; Mikula, M. (2014). mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression. Plos One
Preitschopf, A.; Busch, J.; Zwickl, H.; Nehrer, S.; Hengstschläger, M.; Mikula, M. (2014). Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects. In: Perinatal Stem Cells: 87-98, Springer Verlag
Preitschopf, A.; Zwickl, H.; Li, K.; Lubec, G.; Joo, G.; Rosner, M.; Hengstschläger, M.; Mikula, M. (2012). Chondrogenic differentiation of amniotic fluid stem cells and their potential for regenerative therapy. Stemm Cell Reviews: 1267-74
Rosner, M.; Mikula, M.; Preitschopf, A.; Feichtinger, M.; Schipany, K.; Hengstschläger, M. (2012). Neurogenic differentiation of amniotic fluid stem cells. Amino Acids: 1591-6
Vorträge (Auszug Forschungsdatenbank)
Extracellular vesicles in blood derived products
ICRS Word Congress, 12.01.2023
Extracellular vesicles from blood derived products for cartilage repair
ASEV/GSEV Joint Meeting, 28.10.2022
Extracellular Vesicles in Blood-Derived Products for Cartilage Repair? - a status report
Annual Meeting of the Austrian Cluster of Tissue Regeneration, 27.04.2022
Extracellular Vesicles in Blood-Derived Products for Cartilage Repair
ICRS Word Congress, 14.04.2022
Effects of extracellular vesicles from blood derivatives on osteoarthritic chondrocytes
ASEV/GSEV Joint Meeting, Freising, Deutschland, 28.11.2019
Anti-coagulation influences properties of extracellular vesicles isolated from autologous blood derived products used for cartilage repair
World Congress of the International cartilage repair and joint preservation society, Vancouver, Kanada, 08.10.2019
Current Trends in Regenerative Medicine and Tissue Engineering
BioArt Workshop, Krems, Österreich, 03.06.2019
Coagulation influences properties of extracellular vesicles isolated from autologous blood derived products
TERMIS EU Chapter, Rhodos, Griechenland, 28.05.2019
Blood derived products contain extracellular vesicles with distinct biological properties for regenerative approaches
Word Congress of the International Society of Extracellular Vesicles (ISEV), Kyoto, Japan, 25.04.2019
Die Rolle von extrazellulärem Vesikeln aus Blutprodukten in der Osteoarthrose
Technopol Frühstück, Krems,Österreich, 20.03.2019
Different production technology of blood derived products influences differentiation pathway of various cell populations
World Congress of the International Society of Tissue Engineering and Regenerative Medicine (TERMIS), Kyoto, Japan, 07.09.2018
Different production technology of blood derived products influences differentiation pathway of various cell populations
Gordon Research Conference on Extracellular Vesicles, Newry, USA, 21.08.2018
Different production technology of blood derived products influences differentiation pathway of various cell populations
14. World congress of the International cartilage repair society (ICRS) , Macau, China, 12.04.2018
Inhibierung des mTORC1 Signalweges erhält den chondrogenen Phönotyp von OA Chondrozyten
32. Jahreskongress der GOTS, 24.06.2017
Rapamycin preserves the chondrogenic phenotype and supresses cartilage degrading and inflammatory processes in Osteoarthritis
OARSI 2017 World Congress, 28.04.2017
Strategies for Cartilage Regeneration
14. International Life Science Meeting Krems, 05.04.2017
Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells
Osteoarthritis Research Society International World Congress - Amsterdam, Netherlands, 01.04.2016
The role of the mTOR pathway on the chondrogenic differentiation of human amniotic fluid stem cells
Österreichische Gesellschaft für Orthopädie - Vienna,Austria, 30.10.2015
The role of the mTOR pathway on the chondrogenic differentiation of human amniotic fluid stem cells
Tissue Engineering and regenerative Medicine International Society World Kongress - Boston, USA, 11.09.2015
Rapamycin enhances Sox9 expression during chondrogenic differentiation of amniotic fluid stem cells
4th TERMIS World Congress, Boston, USA, 08.09.2015