Preprint articles are preliminary scientific manuscripts or reports that have not been peer-reviewed yet. Given the new relevance of preprint articles in health sciences, there is a need to describe their publication attributes, methodological characteristics and to assess how results and conclusions change in relation to the peer-reviewed article. It is further unknown how the health research community perceives the growing numbers of published preprint articles. We will adress these issues by undertaking a resarch study using a mixed-methods approach.